Wire numbering
You can configure automatic wire numbering in the program settings (F12) under Document - Wires numbering.
When enable wire numbering is checked, every new wire gets a number automatically. Check pad with leading zeros to pad wire numbers to a fixed number of digits (set in the number of digits field).
Alternatively, you can leave automatic numbering off and number all wires at once after the drawing is finished. The renumber now button does exactly that.